With the NFL season in full swing, next weekend’s matchups promise fireworks—and serious betting potential for the weekend warriors. This week, we’re breaking down two ambitious four-leg parlays: one stacked with player props from yardage to TDs, and another loaded with anytime touchdown scorers. These bets aim to combine high-caliber performers with favorable matchups, positioning the picks to rack up big-time payouts. We’re talking stars set to shine, and with a bit of luck, a healthy bankroll could be just a few drives away. Here’s why each leg has the potential to cash in and bring home those hefty returns we’re in need of this time of year.
The First Player Prop (four legs) [+2514]
Jonathan Taylor over 81.5 rushing yards vs BUF (-120): Jonathan Taylor’s ability to break through defenses makes him an ideal pick to exceed 81.5 yards this weekend. Known for his aggressive north-south running style coupled with sharp cuts and quick decision-making, Taylor has averaged 90.8 yards in his past five games. Buffalo’s defense has shown some vulnerability to powerful ground attacks, particularly when opponents establish early momentum. With Joe Flacco now propelling the offense more efficiently than second-year Anthony Richardson, Taylor is set up for a high-yardage day.
CeeDee Lamb over 6.5 receptions vs PHI (-100): As Dallas’s premier receiving threat and one of the most explosive and consistent receivers in today’s NFL, CeeDee Lamb constantly finds high target volume, especially in tight matchups. Facing Philadelphia means a likely shadow date with Darius Slay, a cornerback who Lamb has posted a 28-282-2 receiving line against in their past 3 matchups. Lamb’s combination of route-running precision and ability to break through man and zone coverage at a high clip should see him surpass 6.5 catches. Dallas has leaned heavily on Lamb in previous high-stakes games, and with their passing game firing, he’s well-positioned to clear this line.
Kyler Murray over 1.5 total touchdowns vs NYJ (+210): Kyler Murray’s dual-threat capability keeps defenses on their toes. While the Jets’s secondary has been top five in the league thus far, they’ve struggled against the league’s top dual-threat quarterbacks, an elite group in which Murray is one of the best performers. Murray’s reliance on timing and mobility could open up opportunities against a New York defense known to struggle against agile quarterbacks. Expect Murray to exploit mismatches in the secondary, particularly in red zone scenarios, making the over on 1.5 TD (through the air or on the ground) a favorable bet.
Devon Achane over 4.5 receptions vs LAR (+130): Achane has emerged as a reliable pass-catcher in short-yardage situations, often serving as a check-down option. With Tua Tagovailoa back at the helm and speedsters Tyreek Hill and Jaylen Waddle running in two-receiver sets, defenses tend to sit in two-high safety looks to protect against the big play. The focus on other offensive threats will leave Achane more than enough room to operate in the short field and turn checkdowns into 10-20 yard gains. The front-line pressure could also lead to more screen opportunities for Achane, increasing his reception chances. Against the Rams’s defense, which has shown inconsistency in covering running backs in the flat, Achane’s role in the passing game should see him clear a lofty running back reception line of 4.5.
The Anytime Touchdown Scorer Parlay (4 legs) [+1088]
Derrick Henry vs CIN (-220): There’s not too much to say about this one. Derrick Henry has been a touchdown machine this year, with 11 TDs through nine games. With preseason concerns over his age, Henry looks as healthy and dominant as ever and is currently leading this top-of-the-league Ravens offense to dominance through Week Nine. Henry’s bulldozing style and unexpected top-end speed make him a nightmare for defenses. This is a leg that should be smashed in any matchup or game environment.
Saquon Barkley vs DAL (-150): After a slower start, Barkley has returned to peak form. Against Dallas, a familiar team with a vulnerable run defense and past struggles to contain agile backs, Barkley is primed to break through for a score. With Dallas’ rush defense ranking in the bottom quarter of the league, Barkley’s prowess and big-play ability make him an ideal choice for an anytime touchdown.
Alvin Kamara vs ATL (+100): Kamara’s versatility as both a rusher and receiver provides numerous scoring avenues, particularly with his knack for exploiting gaps in pass coverage. Facing Atlanta’s middle-of-the-pack defense, Kamara is likely to find space on swing passes or screens, giving him ample red zone opportunities. In a game that should see at least four total touchdowns, he’s a dependable option in high-pressure moments around the end zone.
Davante Adams vs ARI (+145): As one of the league’s top receivers, Adams is a major red zone target. Now that he has reunited with his long-standing quarterback Aaron Rodgers in New York, expect Adams to have another one of his dazzling performances next week. His route-running skills and size advantage give him a scoring edge, particularly against a Cardinals defense that struggles against outside receivers. Expect Adams to capitalize on mismatches and Rodgers to deliver him perfect passes, allowing him to separate from coverage for a score.
As next weekend’s matchup approaches, these bets offer the perfect opportunity to add some thrill to your Sunday afternoon. With each leg based on a combination of player performance history and matchup analysis strategy, there’s a real chance for a huge payout. Sure, it takes a little faith to trust in these performances to string together perfectly—but that’s all part of the excitement. So get ready to watch these stars chase down yardage, find the end zone, and hopefully turn these careful picks into a winning ticket. Game day just got a whole lot more interesting.
Santi Kelly ’26 (skelly@college.harvard.edu) is eager to see how these picks play out on NFL Sunday, where he’ll be tracking these bets as closely as any die-hard fan.